Skye arrived in Pine Valley as a singer and it was discovered that she was Adam's daughter by his first wife. She became the protector of her Uncle Stuart (who seemed to be the only human being able to love and understand her). She had an affair with Tad Martin before "settling down" and marrying Tom Cudahy. As part of an AIDS hate group, Skye set fire to the house where AIDS victim Cindy Parker lived with her son, Scott. When she learned who was inside, Skye decided to brave the flames and rescue those trapped inside. Overcome by fumes while trying to rescue Cindy, Skye fell into a coma for over three months. Skye regained consciousness, but upon doing so she learned that her husband Tom had grown quite fond of Barbara Montgomery. So, Skye decided to continue pretending to be in a coma. She later kidnapped Barbara, an action that prompted Tom to have Skye committed to the Oak Haven sanitarium, where she flirted with fellow patient Travis Montgomery.

Upon her release from Oak Haven, Skye took up with Pine Valley's resident do-gooder, Jeremy Hunter. However her eternal feelings of inadequacy and not being able to live up to Jeremy's expectations led her to drink, and she became an alcoholic. After successfully overcoming her addiction, her father, Adam, concocted a plan to use Skye to spy on his old enemy Palmer Cortlandt. Adam wanted Skye to date Palmer's nephew Will and thereby learn corporate secrets that would allow him to destroy his rival. Little known to them Palmer had the same idea to use Will to gain information on Adam through Skye. Slowly, the two spies fell in love and convinced their families that no useful information could be gained by continuing this maneuver. Adam and Palmer then forbade them from seeing each other, forcing them to set up secret meetings. With the threat of getting caught in yet another lie and not willing to give their relationship a chance, Skye ignored Will's pleas for her to stay in Pine Valley and decided to move to Minnesota to work with recovering addicts.

In an "off screen" development, Skye left for New York City where she met and married the villainous Dr. Jonathan Kinder. Upon finding out that Kinder was using experimental drugs on, and subsequently killing, his patients, Skye planned to report Jonathan to the authorities. Kinder found out, drugged her, and locked her up. When Kinder came to Pine Valley, he brought Skye along with him and hid her in a mansion outside of town. In a twist of fate, fellow town pariah, Janet Green, was captured by Jonathan when she became suspicious of him when she was his secretary, and found that Skye was being held captive. Janet didn't know that Skye was Adam's daughter because she was going by the name Toni- presumably short for Antoinette. While Janet went for help, Skye stumbled onto the Marick Estate and the Hunting Lodge. On this particular night, Dimitri was having an affair with his sister-in-law, Maria.

Subsequent to her gained freedom, Skye was introduced to Edmund Grey. Skye remembered seeing Dimitri and Maria making love, and Skye developed a crush on Edmund. Skye's crush turned to obsession. She thought if she could split up Edmund and Maria, Edmund would be hers. Skye bribed a lab tech, got access to Maria's paternity test and changed the father's name from Edmund to Dimitri.

After the birth of Maria's baby, Maddie, Dimitri was still believed to be the father of the child. Edmund never gave in to Skye's advances and got back together with Maria to raise Maddie. Skye made a promise to herself to tell Edmund that the baby was his. She tried telling him, but she just couldn't bring herself to say it, so she wrote it in a letter and sent it to Maria. Maria did not read it until she was on a plane on her way back to Pine Valley. Maria never got the chance to tell Edmund the good news; the plane crashed and Maria was killed. After Edmund returned home from the hospital, Skye devoted her time to helping him out. Little did she know that he was losing his hearing from time to time. Every time she tried to tell him about the paternity test, he couldn't hear her. Dimitri ended up suing Edmund for custody of Maddie and won. Dimitri took Maddie to the hospital for a check up and found out that Maddie's blood type was different than his; Maddie could not be his biological daughter. Dimitri found out that Skye had changed the paternity test and threatened to kill Skye if she told Edmund about the results swap. Dimitri ended up taking Maddie to Vadzel, his family castle in Budapest. While in prison, Erica revealed that Skye was up to something and she did everything in her power to find out what it was she was doing. Skye confessed that she'd switched the results. Edmund was crushed. He couldn't believe that he'd taken Skye into his life. Skye enlisted the help of her father, Adam, to help her make a clean escape from Pine Valley. Adam urged her to stick around and fight to clear her name. She didn't have the strength to fight and seemingly vanished into thin air, with the help of her dear ole dad.

Skye showed up in Llanview in July 1999 at the request of Asa Buchanan. Asa hoped that she would help him destroy his enemy, Ben Davidson. Skye did this by using Asa's money to bribe a member of the Nevada Medical Board to revoke Ben's medical license. Skye got a job at The Banner, one of Llanview's newspapers, as Styles Editor and became friendly with the publisher, Victoria (Viki) Carpenter. She seemed especially interested in Viki's romantic relationship with Ben Davidson. The reason for this soon became clear. At a party, in front of all of Viki's friends and family, Skye announced that she was Ben Davidson's wife. Ben had thought the marriage was over, since they had filled out annulment papers, but Skye never filed them. Skye resisted all of Ben's attempts to get her to sign divorce papers and dropped another bombshell on Ben. The reason she didn't file for the annulment was that she was pregnant and they have a son together. But Skye soon admitted she was lying; they did not have a child, she just said that to try to hold onto him. Skye eventually agreed to sign the divorce papers and Ben was free to be with Viki.

Skye did not give up on her revenge plot against Ben, though, and blackmailed Max Holden into helping her destroy Ben's life. Skye learned that Max was not the real Buchanan heir and had proof to show the identity of the real heir. Max slept with Skye to convince her to keep quiet about the secret and Skye did keep the secret. She did not, however, keep the details of her relationship with Max a secret. She told Blair about it and Max subsequently left Skye. When Max saw that Blair was out to get him, he quickly put Skye back into his life to keep Blair in line.

Skye was arrested for shooting Max in the back. She was not guilty, however. Blair had shot Max and then Todd had placed the gun in Skye's room to make her look guilty. Skye got some unexpected support from police detective John Sykes, who was dating Rae Cummings and had learned that Skye was Rae's daughter. He convinced her to take a lie detector test, which she passed, and it was enough to get her out on bail.

Skye helped Max with his plan to get Todd to turn on Blair and admit that Blair was the one who shot Max. Max drugged Blair and made it appear they were sleeping together and made sure that Todd saw them. Their plan worked, but they got more than they bargained for. Not only did Todd admit that Blair shot Max, he also announced to a room full of people that Skye was really Rae's daughter. Skye didn't believe it at first, but after Adam came to visit her and admitted that Althea had adopted her as a baby, she knew it was the truth and wasn't happy about it. Once she was cleared of all charges by the D.A., Skye went to see Max and dumped him.

Skye asked Rae who her father was, but Rae refused to tell her until she talked to him first. So when Skye overheard that Rae was going to Port Charles to tell her father about her, she jumped on a plane and got there first. She tailed Rae to General Hospital and saw Rae trying to talk to Alan Quartermaine. Alan was very busy and put Rae off, so she showed up at the Quartermaine mansion that evening, just before Alan and Monica's ceremony to renew their wedding vows. The whole truth came out that Alan's father, Edward, had paid for the baby (Skye) to be taken away and both Alan and Rae were told that the baby had died.

Alan and Edward welcomed Skye to the family, but most of the other family members were not so happy, especially after Edward gave Skye shares in the family company, ELQ. When Skye's new sister, Emily, was in danger, Skye gave her money to leave town, partially to help her and partially because she was jealous of Emily's close relationship with Alan. But Emily didn't make it far out of town, when she was in a train wreck and ended up back in General Hospital, unable to walk. Alan was furious when he later learned about Skye giving Emily the money, but the two later reconciled after Alan accidentally heard Skye speaking at an AA meeting about what had happened. A.J. Quartermaine found out that Skye had given Emily the money and blackmailed her with the information. But as the new brother and sister became closer, A.J. and Skye began to work together to get A.J.'s son Michael back from his ex-wife, Carly.

Skye began falling for the corporate raider Jasper Jacks. He seemed to be the only one able to understand her and care for her despite the things she did to others. When he tried to scare her off by informing her that he didn't feel capable of loving a woman again, Skye took it as a challenge. She created several excuses for Jax to come to her rescue, including faking harassment by Sonny Corinthos. But Skye wound up locked in the boat house for real and escaped by swimming the frigid waters of the lake. Jax found her nearly frozen on the shore and used his body heat to warm her. They became a couple shortly afterwards.

When Edward wanted to take down Jax, he played on Skye's insecurities regarding her relationship with Jax. Skye signed an agreement to use her close relationship with Jax to steal information about his family's holdings. But when Jax proposed to her, Skye wanted out of her deal with Edward. Edward threatened to expose their deal to Jax and had a stroke while arguing with Skye at her engagement party. While Edward was in a coma, Ned discovered a copy of the contract and forced Skye to tell Jax the truth. Coldly, Jax dumped Skye and she went on a drinking binge. She blacked out and woke up later in Edward's room. The plug on his respirator had been pulled, and Skye feared she had done it in a drunken stupor. Afraid of being arrested for murder, she quickly fled and went into hiding. After tricking Edward into "waking up" from his fake coma and confessing that he had pulled his own plug, Jax found Skye and told her she was off the hook. He eventually forgave her and the pair resumed their engagement. After Skye and Jax exchanged vows, a ghost from Jax's past showed up to congratulate him: Brenda. She wasn't dead after all and had stayed away from Port Charles due to her mental illness. Not aware of Brenda's return, Skye was suspicious when Jax postponed their honeymoon to rush off on a secret business mission.

Jax got shot while protecting Brenda and was temporarily paralyzed. Skye finally met Brenda face to face when she found the brunette sitting at Jax's bedside. Upset and jealous at first, Skye was somewhat relieved to learn that Brenda was dying and didn't plan to try to win Jax back from Skye. Skye even encouraged Brenda to continue helping Jax in his recovery. But Jax didn't feel it was right to tie Skye to a crippled husband and enlisted Brenda's help in pushing her away. Hurt, Skye decided to look into Brenda's illness and prognosis. She discovered that the doctor who had diagnosed Brenda's illness had been paid off by Luiz Alcazar to falsely declare Brenda mentally ill. But Skye kept this piece of information to herself. When Jax found out that Brenda wasn't dying and that Skye knew, he demanded a divorce from Skye so that he could be with Brenda. Furious, Skye told Jax he was in for a hell of a fight. Feeling sorry for herself, Skye fell off the wagon and started drinking again. Eventually the divorce went through and Jax got engaged to Brenda. The night of their engagement party at the Quartermaines', both Skye and Alcazar showed up but were thrown out. They ended up in bed together at his hotel suite and Skye passed out afterwards. When she woke up, she heard Brenda arguing with Alcazar in the next room before passing out again. She awoke later to discover that Alcazar had been pushed off the balcony to his death. Seeking revenge on Brenda, Skye told the police she saw Brenda kill Alcazar. But her constant state of drunkenness discredited her testimony. Skye later became the prime suspect after the real killer got Jason and Brenda off the hook. Skye eventually remembered seeing Alexis Davis push Alcazar that night.

Still wanting Jax back, Skye went to his wedding with a loaded pistol in her purse, prepared to shoot the happy bride. But she watched in awe as Jax told Brenda at the altar that he couldn't marry her because she had kissed Sonny Corinthos the night before. Gloating happily, Skye went to see the jilted bride in her suite later to tell her she got what she deserved. Although Jax didn't return to Skye, he did come to her rescue a few more times. When Skye and A.J. kidnapped baby Kristina, Skye confessed her crime to Jax. Jax also helped Skye when Tracy came to town to blackmail Skye with the information that she wasn't a Quartermaine after all. Jax tried to charm Tracy into revealing the proof behind her claim. But Skye decided to just tell the family and Alan surprised them all by stating that Skye would always be his daughter. When Rae finally confirmed Tracy's allegations, Skye announced she no longer had a mother. Jax tried to cheer Skye by getting Ned to offer her a job at ELQ. Alan later legally adopted the adult Skye as his own child.

After bonding with baby Kristina during her kidnapping, Skye decided she wanted her own child and asked Jax to father it. He turned her down and Skye later found out that she wouldn't be able to carry a baby to term. Devastated, Skye became somewhat fixated on Ned and baby Kristina. Skye became a sort of surrogate mother for Kristina since Alexis wasn't allowed custody of her daughter. Skye tried to get Alexis out of Kristina's life for good by bringing over Alcazar's look-a-like brother, hoping that Alexis would freak out. But Alexis didn't react, which made Skye suspicious that Alexis was faking her illness. When Skye figured out that the new Quartermaine butler was really Alexis in disguise, she tricked Alexis into revealing everything, including faking her illness, to the judge. Alexis retaliated by getting Stefan to discredit Ned so that Alexis would gain custody of her daughter. When the girl Stefan had hired to accuse Ned of rape was later proven to be lying, Alexis was arrested for hiring the girl. During her trial, Ned tried to fight Alexis for custody and sued her for slander. But in the middle of the trial, he dropped his pursuit of custody. Furious, Skye then dumped Ned. She moved out the mansion and back to the lake house she had shared with Jax.

But soon Skye wasn't alone in her new abode. Luke had decided to hide out from the cops at the lake house and convinced Skye to help him continue to hide. Although she verbally protested, she continued to cover for Luke whenever someone came looking for him. They decided to pair up to dupe the Quartermaines out of money so that Luke would have some cash to go on the run with. But soon he happened upon the Dead Man's Hand. Skye didn't believe the old cards were worth anything until Jax reappeared in town in pursuit of them. Still having a soft spot for Jax and his family, Skye tricked Luke and gave Jax one of the cards that Luke had stolen from A.J. But Skye was less than thrilled to learn that Jax seemed to have a new woman in his life: Sam.

Skye saw through Sam right away and tried to get her to leave Jax alone. After the hunt for the Dead Man's Hand ended in John Jacks' death, Skye expressed her sympathies to Jax. Then she became partners with Luke and Sam in a new casino on the ship the Haunted Star. Luke managed to dupe Sam out of her ownership of the boat. When he found some money hidden aboard and used it to fund the new casino, Faith showed up and claimed the money as hers. So Faith became a partner in the casino as well. When Luke took off and left a note that he was "gone fishing" right before opening night, Skye was forced to work with Faith by herself. When the casino was robbed on opening night, Skye accused Faith of being behind it. In order to protect Luke and herself from Faith, Skye had Justus draw up a contract and made Faith sign it.

Luke finally returned to town and Skye chewed him out for leaving her to deal with opening night. But Luke had bigger things on his mind, including a sunken treasure which had brought Helena back to town. He planned to steal it on the night the Cassadines and Quartermaines were auctioning it off. When a fire broke out at the PC Hotel where the auction was taking place, Skye found Luke unconscious in a janitor's closet. She revived him and together they eventually made their way to the Versailles Room. Luke quickly took charge of the chaos there and made everyone draw numbers to determine the order they would be rescued by helicopter. Luke tried to give Skye his number but she refused. When it came time for him to leave, Skye ran out to the landing pad and gave him a passionate kiss goodbye. Later, after the fire was over and they were both safe, they tried to pretend that the kiss never happened.

Before the fire, Edward had altered his will to make Skye his sole heir despite not being a real Quartermaine. Thrown for a loop by the news, Skye nearly fell off the wagon again, helped by Tracy who wanted ELQ for herself. But Luke snapped Skye out of it and she vowed to take on Tracy sober. Since the Quartermaines were in danger of being held liable for the fire at the hotel, Justus and Tracy persuaded Edward to act senile in order to escape liability. But Tracy wanted to take full advantage of the situation and have Edward committed to a mental hospital. So Edward escaped and Skye and Luke hid him at her lake house.

Their romance would always be paved with detours. When Luke married Tracy to get his hands on Helena's stolen millions, Skye realized that she and Luke were not destined to be together. She moved on with Lorenzo Alcazar. Initially the relationship was casual but both, having been hurt by people they loved, started opening up to each other. When a deadly virus swept Port Charles and Skye fell ill, Lorenzo made the decision to switch Skye's medical chart with Lulu Spencer's so that Skye would receive one of the few doses of the antidote that they hospital had. Skye would resent Lorenzo for risking Lulu's life for hers. Eventually though, Skye does forgive Lorenzo and they resume their relationship.

Skye was given a miracle when she learned that she was pregnant. Realizing what a gift she had been given, Skye was determined to keep her child from the violence that plagued Lorenzo, the baby's father. Lorenzo Alcazar was not happy with the decision and tried everything to convince Skye to reconsider. Skye refused and turned to Robert Scorpio for help. He managed to help Skye flee the country so that she could have her baby in peace and live in safety far from Lorenzo's reaches. They underestimated Lorenzo's determination. He caught up with Skye just as she went into labor. The birth of her daughter, Lila Rae, changed Skye profoundly. She realized that she had no right to deny Lila a relationship with her father. To protect that connection, Skye would make some heart breaking decisions that would drive a deep rift through her family.

When one of Lorenzo's associates took the Metro-Court hostage, Skye decided to protect Lorenzo's secrets not realizing that at that very moment her father, Alan, was inside the Metro-Court suffering what would prove to be a fatal heart attack. Skye was devastated at the loss of her father even more so when she realized that Lorenzo had lied to her. Thinking that Lorenzo had amnesia, Skye felt she had no choice but to temporarily run Lorenzo's criminal empire. It put both Skye and Lila in a very dangerous situation but more than that, it showed Skye that Lorenzo did not fully trust her. Skye decided to leave Lorenzo only to learn that he was not going to let her go with their daughter. Having recently lost his son Diego to mob violence, Lorenzo saw Lila as his last hope at happiness. He had his daughter spirited out of town and refused to let Skye know where she was. Skye grew desperate, fearing what Lorenzo's upbringing may do to their daughter. Skye felt she had no choice but to turn to Lorenzo's rival, Sonny Corinthos and her brother, Jason Morgan for help. Jason and Skye were anything but close but they both loved Alan so they were united in seeing Lorenzo pay for his role in his death. As planned, Skye pretended to reconcile with Lorenzo until she earned enough of his trust to decide to bring their daughter home. The moment Lila was returned to Skye she contacted Sonny and let him know. On the eve that Lorenzo intended to take Skye and Lila out of the country to start their new chapter as a family, Skye let Jason into their home. Skye was with Lila Rae, rocking her and singing a lullaby, while in another room Jason shot and killed Lorenzo.

Skye pretended that Lorenzo had left her and cut off all contact with her. Ric didn't believe her and eventually found a tape that recorded Lorenzo's murder. Unfortunately he failed to convince a jury. Skye stuck to her story that she had no knowledge of Lorenzo's murder and Carly and Jerry Jacks manufactured evidence that Lorenzo was alive and well.

In the aftermath of Lorenzo's disappearance, Skye was in control of Lorenzo's waterfront property, which was highly coveted by both Sonny and Trevor Lansing. Trevor was running the Zacchara organization and realized control of Lorenzo's property would allow them to better compete with the Corinthos organization. Skye was not interested in selling to either party. Trevor enlisted his son Ric in the pursuit of the property. He suggested Ric flirt with Skye to sway her in their favor. Ric was not sure if he wanted his brother or his father to have the property, but he did try to pursue a relationship with Skye. She was tempted by Ric's need for control and agreed they could be a power couple in Port Charles and they exchanged a few kisses. In the end she refused to enter into a relationship with Ric because it would lead her down the same path she had already taken with Lorenzo. Skye decide to leave Port Charles with Lila Rae, but she presented Ric with the parting gift of the deed to the property.

A few years later, Skye returned to Port Charles. Edward and Luke were thrilled, although Luke questioned why Skye was back. Skye was embarrassed to admit she was out of money and the reason for her return was to track down Lorenzo's hidden assets. Luke was intrigued by Skye's predicament and she agreed to give Luke a portion of the hidden money if Luke helped her locate it. Tracy was concerned when she learned Skye and Luke were teaming up together. Skye enjoyed preying on Tracy's insecurities and flirted with Luke in front of Tracy.

Skye stopped by the lake house where she used to live. Alexis Davis and her daughters currently lived there. Kristina was home recovering from the physical abuse she suffered from her boyfriend Kiefer Bauer, although Kristina had accused Luke's son Ethan. While Skye and Kristina visited, Skye realized a source of Kristina's pain was her feelings of guilt over what she was putting Ethan through. Skye took Kristina to visit Ethan and helped her mend her relationship with him.

Skye and Luke were unable to find Lorenzo's hidden assets and when Skye realized Tracy and Luke were truly in love she turned to Jax for help instead. He and Carly were separated and Skye offered to help Jax win Carly back since he was assisting her in tracking down Lorenzo's money. Skye convinced Jax to pretend to pursue her in order to make Carly jealous. Jax and Skye went to Barcelona together and located Lorenzo's money. While they were in Barcelona, Skye told Jax she had developed real feelings for him again and would like another chance at a relationship with him. He told Skye he was flattered but his heart still belonged to Carly and he wanted to give his marriage to her one more try.

In 2011, Skye was lured back to Port Charles through her association with Anthony Zacchara, although she claimed she had returned to attend a fundraiser. Tracy suspected Skye was back to get her hands on the Quartermaine fortune and the women fell into their familiar routine of exchanging verbal barbs, whereas Edward welcomed Skye home with open arms.

Skye kept her partnership with Anthony secret and the pair met often. They discussed the money Skye would receive from Anthony after she handed over the proof that years ago, Tracy had used the mob money she had inherited from Gino Soleito, her deceased husband, to restore ELQ. Skye did not care how Anthony used the information against Tracy as long as Edward was not hurt in the fallout. Anthony agreed to the terms.

While Skye waited for her deal with Anthony to be complete, Jason was involved in a car accident and required a risky brain surgery. Edward was deeply concerned about Jason and Skye kept a close watch over Edward to make sure his health did not decline under the stress. Skye also helped out Jax after he was involved in a plane crash and presumed dead. She provided him with the clothes and money that allowed him to quietly sneak out of town. Jax thanked Skye for her assistance and warned her to be cautious in her dealings with Anthony.

After Skye received her payment from Anthony, she believed they were done working together but Anthony did not agree. He repeatedly threatened Skye and made threats about the safety of her daughter. Skye turned to Luke's son Ethan for protection against Anthony until she figured out her next move. She warned Edward that ELQ would be in danger when secrets from Tracy's past made their way to the present and she took Edward's offer to use the Quartermaine jet to leave town. Before she left, Skye had a brief reunion with Luke and encouraged him to check on his family.

Skye returned to Port Charles with her daughter in 2012 after she received word that Edward had passed away. Skye entered the parlor and came upon Heather Webber. The women recognized one another immediately and Heather held a knife to Skye's throat and attempted to take her hostage. Alice intervened and freed Skye from Heather's clutches. Skye remained in town a few days longer and encouraged A.J. to oust Tracy at the helm of ELQ.

Skye's attention shifted from ELQ after she saw a picture of a man that looked like Lorenzo. The man in the picture was named Tomas Delgado and he was engaged to marry Skye's nemesis from Llanview, Blair Cramer. Skye's other archenemy, Carly, also saw the picture and agreed that "Tomas" must be Lorenzo. They traveled to Llanview with Todd Manning in order to determine if Tomas was actually Lorenzo. They met with Blair and Tomas' sister Téa and the women insisted that Tomas could not be Lorenzo.

The women waited for Tomas to arrive but he never did. Instead, a CIA agent arrived and announced that Tomas had been recalled by the CIA regarding a case. Skye insisted that she needed to know if her child's father was alive and she took off with Téa and Blair to find him.